Mouth dissolving tablets (MDT) constitute an innovative dosage form that overcome the problems of swallowing and provides a quick onset of action. The aim of the present research was to prepare oral dispersible tablets by sublimation method and investigate the effects of superdisintegrant (kyron T-314) on the disintegration time. Rizatriptan benzoate, anti-migrain drug was selected as the model drug for the study. A high porosity was achieved using camphor as volatilizing agent. Tablets were prepared using a direct compression method employing superdisintegrants such as kyron T-314, crospovidone, croscarmellose sodium and sodium starch glycolate. In-vitro release studies were performed using USP apparatus-II (paddle method) in 900 ml of 0.1N HCl (pH 1.2) at 50 rpm. Tablets of rizatriptan benzoate prepared using kyron T-314 exhibited the least friability and disintegration time 34.33 seconds. The addition of camphor as a subliming agent lowered the disintegration time to 30.33 seconds. A 32 full factorial design was employed to study the joint influence of the amount of superdisintegrant (kyron T-314) and the amount of sublimating agent (camphor) on the percent of friability and the disintegration time. The results revealed that an effective MDT of rizatriptan benzoate requires higher percentages of kyron T-314 and camphor should be used. Stability studies revealed that were no significant changes in the formulation Thus, it was concluded that by adopting a systematic formulation approach, rizatriptan benzoate mouth dissolving tablet could be formulated using superdisintegrants in combination with a vacuum-drying technique for improved therapeutic efficacy.
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